SILENCING OF PARP2 BLOCKS AUTOPHAGIC DEGRADATION

Silencing of PARP2 Blocks Autophagic Degradation

Poly(ADP-Ribose) polymerases (PARPs) are enzymes that metabolize NAD+.PARP1 and PARP10 were previously implicated in the regulation of autophagy.Here we showed that cytosolic electron-dense particles appear in the cytoplasm of C2C12 myoblasts in which PARP2 is silenced by shRNA.The cytosolic electron-dense bodies resemble autophagic vesicles and, i

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Activities of civic organizations in the field of protection of prisoners and rehabilitated persons in the soviet period legal assessment of russian crimes in Ukraine

Purpose.The purpose of the publication is to reveal the degree of involvement of public institutions in the protection of the rights of prisoners and rehabilitated persons in the Ukrainian SSR in the 1960s-1980s.Methods.The methodological basis of the research was a set of principles of historicism, objectivity, as well as general scientific, speci

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Immigration, Cosmopolitanism, and the Opening of Borders .

The paper critically examines the forms the idea of cosmopolitan hospitality takes both in the contemporary debate on the political rights of immigrants, and on the problem of global justice.Showing that the original mitigated gall Kantian meaning of hospitality presents some important limits in terms of the problems which edible bra and panty set

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